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Observe Closely (one)pentobarbital will decrease the level or impact of glecaprevir/pibrentasvir by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will minimize the level or influence of etravirine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.pentobarbital will lower the extent or effect